Game Info
Kickoff: Sunday, November 15, 2026, 4:25 PM ET
Location: AT&T Stadium, Arlington, TX
Network: FOX
San Francisco 49ers
Quarterback
Brock Purdy: START, QB1
Brock Purdy belongs in your lineup. He’s Olive Garden. Everybody loves to act like they’re above it, but somebody keeps ordering another basket of breadsticks.
Running Back
Christian McCaffrey: START, RB1
Kaelon Black: SIT
Remember that whole thing about running backs past the age of 28 being doomed for fantasy failure? 30-year-old Christian McCaffrey just scored in his seventh straight game, his seventh straight with at least 16 fantasy points, and currently sits as the RB3 in points per game this season. Kaelon Black saw double-digit touches and averaged more than five yards per carry for the second straight game last week against the Raiders, but unless CMC goes down, he’s nothing more than a high-end handcuff.
Wide Receiver
Deebo Samuel Sr.: START, WR3
Keenan Allen: START, WR3
Mike Evans: SIT
The 49ers are apparently collecting the infinity stones of top receivers from 2021. With Mike Evans out indefinitely, the Niners added Keenan Allen, who could find himself settled in as the team’s WR1 if Deebo Samuel isn’t able to return from his hamstring issue. If both are active, both are startable as WR3s with a juicy Dallas matchup on deck. If Deebo sits, I just may push Allen into back-end WR2 territory.
Tight End
George Kittle: START, TE1
George Kittle is tied for third among tight ends in red zone targets per game, and this game has the highest total of the week at 55.5. The TE4 on the season is locked into your lineup.
Defense/Special Teams
San Francisco 49ers: SIT
Did you read what I said about the game total in Kittles blurb?
Dallas Cowboys
Quarterback
Dak Prescott: START, QB1
The Niners have held most quarterbacks in check this season, but the game is in Dallas with a mid-50s implied total, and San Fran gave up three passing touchdowns on the road to Michael Penix Jr. just a few weeks ago. His yardage is likely low, but Dak Prescott should throw for multiple touchdowns and is a QB1 despite the less-than-ideal defensive matchup.
Running Back
Javonte Williams: START, RB1
Tyler Goodson: OUT
Javonte Williams is a lock for close to 20 touches a week and ranks first at the position in goal line carries. He’s a matchup-proof start and an RB1 against the Niners in the highest projected game total of the week.
Wide Receiver
CeeDee Lamb: START, WR1
George Pickens: START, WR2
Ryan Flournoy: FLEX, WR4
There’s no overthinking starting CeeDee Lamb. He’s Red Lobster. You can have plenty of questions about the rest of the operation, but nobody’s questioning the Cheddar Bay Biscuits. George Pickens missed Week 9 and is in danger of missing Week 10 as well. At the time of writing, Pickens had only practiced in limited fashion, which he did last week before missing the game. Keep an eye on practice reports; he’s the type of talent that, if he’s active, he’s starting for your fantasy team. Ryan Flournoy is FLEX-worthy with or without Pickens in the lineup.
Tight End
Jake Ferguson: OUT
Brevyn Spann-Ford: SIT
Jake Ferguson is out with a knee injury. Brevyn Spann-Ford is next in line, but he isn’t a fantasy option.
Defense/Special Teams
Dallas Cowboys: SIT
San Francisco has allowed the fewest sacks in the league and scores the third-most points.