Week 4 presents some challenging situations for several elite running backs. Christian McCaffrey, Bijan Robinson, Jonathan Taylor, and Jahmyr Gibbs all face top-five run defenses that allow the fewest fantasy points per game to the position. The biggest concern may be Jonathan Taylor, even after his explosive performance last week. The Rams just held Saquon Barkley under 60 total yards, showing how tough this matchup can be. –Steve Pintado
One back I’m excited to see climb the ranks is Omarion Hampton. With Najee Harris out for the season (Achilles), Hampton steps into a strong matchup against the Giants, who are surrendering the third-most fantasy points per game to running backs (per Pro Football Reference). –Steve Pintado
Week 3 brought more injuries, with James Conner and Tyrone Tracy both expected to miss extended time. That opens the door for Trey Benson as a viable Week 4 streamer against the Cardinals, a below-average run defense that also allows the third-most receptions to running backs. -Steve Pintado
You may want to be a bit more cautious with Cam Skattebo against the Chargers. L.A. ranks near the top in run-defense efficiency, but they also give up plenty of RB receptions, an area where Skattebo flashed last week with six catches. -Steve Pintado
A sneaky Week 4 play could be the Houston backfield featuring Nick Chubb and Woody Marks. With the team unlikely to rush Joe Mixon back, this duo gets a juicy matchup versus the Titans, who have allowed the second-most fantasy points per game to RBs, including a league-high five rushing touchdowns. –Steve Pintado