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RB Rankings: Week 16
| Rank | Name | Team | Position | Opponent |
|---|---|---|---|---|
| 1 | Saquon Barkley | PHI | RB | @ WAS |
| 2 | Jahmyr Gibbs | DET | RB | @ CHI |
| 3 | Josh Jacobs | GB | RB | vs NO |
| 4 | Bijan Robinson | ATL | RB | vs NYG |
| 5 | James Conner | ARI | RB | @ CAR |
| 6 | Derrick Henry | BAL | RB | vs PIT |
| 7 | Chase Brown | CIN | RB | vs CLE |
| 8 | De’Von Achane | MIA | RB | vs SF |
| 9 | Kyren Williams | LAR | RB | @ NYJ |
| 10 | Chuba Hubbard | CAR | RB | vs ARI |
| 11 | James Cook | BUF | RB | vs NE |
| 12 | Bucky Irving | TB | RB | @ DAL |
| 13 | Joe Mixon | HOU | RB | @ KC |
| 14 | Breece Hall | NYJ | RB | vs LAR |
| 15 | Zach Charbonnet | SEA | RB | vs MIN |
| 16 | Isaac Guerendo | SF | RB | @ MIA |
| 17 | Jonathan Taylor | IND | RB | vs TEN |
| 18 | Aaron Jones Sr. | MIN | RB | @ SEA |
| 19 | Jerome Ford | CLE | RB | @ CIN |
| 20 | Brian Robinson Jr. | WAS | RB | vs PHI |
| 21 | Rico Dowdle | DAL | RB | vs TB |
| 22 | Tony Pollard | TEN | RB | @ IND |
| 23 | Rachaad White | TB | RB | @ DAL |
| 24 | Rhamondre Stevenson | NE | RB | @ BUF |
| 25 | D’Andre Swift | CHI | RB | vs DET |
| 26 | Isiah Pacheco | KC | RB | vs HOU |
| 27 | Tyrone Tracy Jr. | NYG | RB | @ ATL |
| 28 | Tank Bigsby | JAC | RB | @ LV |
| 29 | Kendre Miller | NO | RB | @ GB |
| 30 | Najee Harris | PIT | RB | @ BAL |
| 31 | Travis Etienne Jr. | JAC | RB | @ LV |
| 32 | Jaylen Warren | PIT | RB | @ BAL |
| 33 | Tyjae Spears | TEN | RB | @ IND |
| 34 | Gus Edwards | LAC | RB | vs DEN |
| 35 | Javonte Williams | DEN | RB | @ LAC |
| 36 | Tyler Allgeier | ATL | RB | vs NYG |
| 37 | Kimani Vidal | LAC | RB | vs DEN |
| 38 | Justice Hill | BAL | RB | vs PIT |
| 39 | Ameer Abdullah | LV | RB | vs JAC |
| 40 | Kenneth Gainwell | PHI | RB | @ WAS |
| 41 | Kareem Hunt | KC | RB | vs HOU |
| 42 | Raheem Mostert | MIA | RB | vs SF |
| 43 | Blake Corum | LAR | RB | @ NYJ |
| 44 | Devin Singletary | NYG | RB | @ ATL |
| 45 | Ty Johnson | BUF | RB | vs NE |
| 46 | Isaiah Davis | NYJ | RB | vs LAR |
| 47 | Antonio Gibson | NE | RB | @ BUF |
| 48 | Cam Akers | MIN | RB | @ SEA |
| 49 | Sincere McCormick | LV | RB | vs JAC |
| 50 | Braelon Allen | NYJ | RB | vs LAR |
| 51 | Jaleel McLaughlin | DEN | RB | @ LAC |
| 52 | Ray Davis | BUF | RB | vs NE |
| 53 | Alexander Mattison | LV | RB | vs JAC |
| 54 | Patrick Taylor Jr. | SF | RB | @ MIA |
| 55 | Audric Estime | DEN | RB | @ LAC |
| 56 | Jeremy McNichols | WAS | RB | vs PHI |
| 57 | Craig Reynolds | DET | RB | @ CHI |
| 58 | Jaylen Wright | MIA | RB | vs SF |
| 59 | Sean Tucker | TB | RB | @ DAL |
| 60 | Roschon Johnson | CHI | RB | vs DET |
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