Welcome to the Week 6 of the 2021 NFL season! Week 6 represents the first of nine bye weeks this season with the 49ers, Falcons, Jets, and Saints all off. The Buccaneers head to Philadelphia to open up the week tonight, while the AFC leading Bills take on the Titans in Tennesee to wrap the week up on Monday.
Join us as we go game by game, breaking down each matchup as we help you make sense of the new season while setting your lineups for Week 6. These Sit/Start determinations have been made with a 2 RB, 3 WR, Flex roster in mind, and with 1 point per reception. Look for us each Thursday on Reddit as well, where we answer every question thrown our way, and check out our Sit/Start Podcast.
Best of luck in Week 6!
Mayfield: Photo by Cody Glenn/Icon Sportswire
Murray: Photo by Michael Allio/Icon Sportswire
Feature Graphic Designed by James Peterson (Follow @jhp_design714 on Instagram & Twitter)