Game Info
Kickoff: Thursday, October 10th, 2024, 8:15 ET
Location: Lumen Field, Seattle, Washington
Network: Prime Video
San Francisco 49ers
Quarterback
Brock Purdy: Start, QB1
Purdy has been playing with confidence, and the Seahawks don’t exactly have a lockdown defense. He’s a safe bet for low-end QB1 production and could even surprise you with a bigger game if things break right. He has an opportunity to do that as he gets more in sync with Brandon Aiyuk, like he started to last week.
Running Back
Jordan Mason: Start, RB1
Jordan Mason is set up for a nice outing, as the 49ers will likely lean on their run game. With Seattle being middle-of-the-road in terms of points to opposing RBs (14th most), he’s a solid start once again in what could be a physical game. His total control of the 49ers backfield makes him one of the safest starts every week.
Wide Receiver
Brandon Aiyuk: Start, WR1
Deebo Samuel Sr.: Start, WR2
Jauan Jennings: Sit, WR5
Brandon Aiyuk has struggled to get going for most of the season, but in Week 5, he hauled in eight targets for 147 receiving yards. He gets a nice matchup against a Seahawks defense that’s had its ups and downs. He’s a WR1 this week and should be locked into your lineups. Deebo Samuel has been underperforming since he returned from injury this season, posting just shy of 100 yards over his last two games combined. Samuel is the most versatile player on the Niners, though, so he will always be involved when healthy, and he’s got the matchup to deliver WR2 numbers. Jauan Jennings is too far down the pecking order when the Niners pass-catchers are healthy to start with any confidence. Leave him on the bench unless you’re in a super-deep league and feeling lucky. He had a nice blow-up week but has returned to his limited target share and snap count.
Tight End
George Kittle: Start, TE1
George Kittle has been nothing short of reliable, finishing as a top-five tight end for three straight weeks and never dipping below TE10. He’s in a good spot again for Week 6, especially with Christian McCaffrey still out of the lineup, giving Kittle even more opportunities to shine. The Seahawks aren’t great at defending tight ends (13th most points against), so expect some highlight-worthy plays.
Seattle Seahawks
Quarterback
Geno Smith: Sit, QB2
Geno Smith has been a strong performer this season, but this isn’t the matchup to roll the dice on. The 49ers’ defense is tough, making Geno a risky play this week. If you are desperate for a fill-in because of Bye weeks, you could certainly do worse–Geno is my QB16 on the week.
Running Back
Kenneth Walker III: Start, RB1
Zach Charbonnet: FLEX Option, RB3
Walker’s volume and talent make him a must-start, even in a tough matchup. The 49ers’ defense won’t make it easy, but he’s got enough juice to deliver RB2 numbers with RB1 upside. He has yet to produce less than double-digit fantasy points this season and has not fallen below the RB15 in any given week. Zach Charbonnet is a deeper FLEX play with some upside if Seattle uses a committee approach. He’s more of a “break glass in case of emergency” option, though. He has enough passing-down work to flirt with RB2 numbers from time to time, but as long as Walker is healthy, his ceiling is capped.
Wide Receiver
DK Metcalf: Start, WR1
Jaxon Smith-Njigba: FLEX Option, WR3
Tyler Lockett: Sit, WR5
DK Metcalf is the kind of guy who can score on any given play, and even though the 49ers present a challenge, he’s talented enough to produce WR1 numbers as the team’s top target. The new offensive system has allowed Metcalf to reach a whole new level as a player. Get him in your lineup. JSN has some appeal as a FLEX play, particularly in PPR leagues. He’s been getting more involved and could have a decent game if the Seahawks fall behind, but his matchup in the slot against Deommodore Lenoir is challenging. The other thing that could limit him is if both teams turn to the run early. Tyler Lockett has been quiet this year, and this matchup doesn’t scream breakout potential. He’s a bench option unless you’re in a deep league and out of alternatives.
Tight End
Noah Fant: Sit, TE2
Fant hasn’t been involved enough to warrant a start, especially against a 49ers team that knows how to handle tight ends.