Sit/Start 2025 Week 10: Reviewing All Fantasy Relevant Players in Every Game

Sit or Start recommendations for EVERY fantasy-relevant player in Week 10 of the 2025 NFL season!

Game Info

 

Kickoff: Sunday, November 9, 2025, 9:30 AM ET

Location: Olympic Stadium Berlin, Berlin, DEU

Network: NFLN

 

Atlanta Falcons

 

Quarterback

Michael Penix: SIT, QB2 (Startable in Superflex)

After missing one game due to injury, Michael Penix returned in Week 9 to face the Pats and became the first quarterback to toss three touchdowns against them this season. It was one of his best fantasy performances of the season, but he wasn’t very efficient. Penix went 22/37 for 222 yards, completing less than 60% of his passes, and threw for fewer than 250 yards for the fourth time in seven starts. He had a strong enough showing to be a solid superflex starter facing the Colts, but he’s a risky start in 1QB leagues. Indianapolis allows the 12th most points to the position, but has held the past two quarterbacks faced (Cam Ward, Aaron Rodgers) to under 300 yards and one score. 

 

Running Back

Bijan Robinson: START, RB1
Tyler Allgeier: SIT

You already know to start Bijan Robinson, but did you know that through his first 42 career games, he has almost as many 100-yard receiving games (3) as all other NFL running backs combined in the league during the same span (4 games for all other RBs)?

 

Wide Receiver

Drake London: START, WR1
Darnell Mooney: SIT

All three of those Michael Penix touchdowns went to Drake London, who made one spectacular catch after another all game long. London had 9 catches on 14 targets for 119 yards and the trio of touchdowns. He accounted for 38% of the Falcons’ targets, and it was his fourth straight game with 10+ targets. He’s a tad more volatile than you’d like to see from your top fantasy receiver, but there’s no question he’s a WR1. In his three games since returning from injury, Darnell Mooney has a total of five catches and 11 targets. He’s still worth stashing, but is unstartable in all formats.

 

Tight End

Kyle Pitts Sr.: START, TE1

Over the last three games, Kyle Pitts has had a 24.5% target share for the Falcons, second only to Drake London. Even if you throw away that fever dream of a game with Kirk Cousins, Pitts is still second, and the share slightly drops to 22.7%. He’s yet to have a monster game, but against a Colts defense allowing the fourth most points to the position, Week 10 is as good a matchup as any to finally unleash the beast.

 

Defense/Special Teams

Atlanta Falcons: START

The Falcons are holding teams to 282.5 yards per game, fourth lowest in the league. 

 

Indianapolis Colts

 

Quarterback

Daniel Jones: START, QB1

It technically wasn’t the lowest fantasy output Daniel Jones has had since joining the Colts, but it was by far his worst game. Jones went 31/50, 342 yards, 1 TD, 3 INT. He did rush for a touchdown, but fumbled the ball three times, losing two. Five turnovers. Per Nextgen stats, Jones had a 46% completion rate and threw 2 INT while pressured, facing it a season-high 18 times. Jones was fine when he had time, 254/342 yards came with a clean pocket, 68% completion, one TD, and one INT.

It’s far from time to panic, but this was a meltdown of Giant proportions for Jones. His issue has always been facing pressure, but the Colts have done a good job of keeping it off him so far this season. If this becomes a trend, Jones’ career revival could be short-lived. Even after allowing four touchdowns to Tua Tagovailoa in Week 8, the Falcons are allowing the sixth-fewest fantasy points to opposing quarterbacks. Indiana Jones is still a start, but his upside is nerfed with such a tough matchup. 

 

Running Back

Jonathan Taylor: START, RB1

I probably don’t have to mention starting Jonathan Taylor, but did you know that in 2021, he had a streak where he recorded a touchdown AND a 20+ yard run in 11 straight games? No running back had achieved a streak like that since LaDainian Tomlinson in 2006.

 

Wide Receiver
Tight End

Michael Pittman Jr.: START, WR1
Alec Pierce: START, WR3
Josh Downs: FLEX, WR4
Tyler Warren: START, TE1

I decided to lump together the wide receivers and tight ends for the Colts this week because maybe more so than any other team, the two units are impacting each other so drastically. Over the first six weeks, Tyler Warren was the early favorite for rookie of the year and commanding a team-leading 21.3% target share. Michael Pittman Jr. wasn’t far behind with 20.2% of targets, followed by Josh Downs and Alec Pierce. But since Week 7, Warren has fallen all the way to fourth on the pecking order. Pittman is seeing one out of every four Daniel Jones throws, and his passes to Pierce have proliferated to 23.5%. Downs has seen a slight downtick, but has a score in three straight.

 

Colts Wide Receiver Trends

 

So what’s all this mean, exactly? For Pittman, he’s even more locked in as a weekly WR1. Pierce becomes a dangerous WR3 with a decent floor and week-winning upside. Downs is about the same, albeit with a little more volatility. But Warren? Blargh. He’s no longer a fun fact status, but still sees enough volume to be considered an every-week start. The Falcons may prove difficult for both units, as Atlanta allows the seventh-fewest points to receivers and the fewest to tight ends. It may sound counterintuitive, but I’m still comfortable starting all four. The range of outcomes is a bit wider than usual, but they have stable enough floors that the gamble is well worth it.

 

Defense/Special Teams

Indianapolis Colts: START

One of the top units in all the NFL got even better with the addition of shutdown cornerback Sauce Gardner via trade with the Jets. The Colts were already top five in sacks, turnovers, and allowing just over 20 points per game. Let’s go to our very own Brian Hartman for his analysis of the deal.