Game Info
Kickoff: Sunday, September 28, 2025, 4:05 p.m. ET
Location: SoFi Stadium, Inglewood, CA
Network: FOX
Indianapolis Colts
Quarterback
Daniel Jones: START, QB1
Danny Dimes. Indiana Jones. Whatever you want to call him, you also have to call Daniel Jones a must star…
OK. Sorry. I can’t get there just yet. But he’s coming pretty, pretty close. Jones is coming off his first game not scoring multiple touchdowns, but he has passed the eye test with flying colors in Indy. Before giving up three passing touchdowns to Jalen Hurts, the Rams held Cam Ward and C.J. Stroud to a combined one touchdown and 363 passing yards. Indianapolis Jones is startable in all formats.
Running Back
Jonathan Taylor: START, RB1
Tyler Goodson: SIT
DJ Giddens: SIT
You don’t need me to tell you to start Jonathan Taylor. But did you know he married his college sweetheart, Ayanna Chapman? She was also a college athlete, a standout hurdler for the Wisconsin track and field team.
Wide Receiver
Michael Pittman Jr.: START, WR2
Alec Pierce: SIT
Josh Downs: SIT
Michael Pittman leads all receivers and is just barely behind Tyler Warren with a 21.6% target share. He’s the WR1 for the emerging Colts offense and scored a touchdown in two of three games. Pittman is a WR2 facing off against a Rams defense that just gave up receiving touchdowns to both A.J. Brown and DeVonta Smith.
Tight End
Tyler Warren: START, TE1
Tyler Warren is getting pretty close to “fun fact” status, but he’s not quite there yet. Warren leads the Colts in both target share (22.7%) and yards per route run (2.5). The Rams haven’t given up much to tight ends so far this season, but Warren is Jones’ favorite target. He’s starting anywhere you have him,
Defense/Special Teams
Indianapolis Colts: STREAMER (Three Weeks)
The Colts D/ST is tied with multiple teams at five takeaways, the fourth-highest total in the league, and is holding opposing teams under 20 points per game. With games against Las Vegas and Arizona on deck, Indy is streamable for up to three weeks.
Los Angeles Rams
Quarterback
Matthew Stafford: START, borderline QB1
As long as Matthew Stafford is on the field and throwing to Puka Nacua and Davante Adams, he’s a streamer more often than not. With one of the highest implied team totals and game totals on the week, he’s a borderline QB1.
Running Back
Kyren Williams: START, RB2
Blake Corum: SIT
The Colts have allowed two rushing touchdowns on the season and have yet to allow a 100-yard rusher. I’m going to copy and paste this part every week, because it continues to hold. Kyren Williams is an efficient, volume-based RB2 who can finish as an RB1 if he scores a touchdown.
Wide Receiver
Puka Nacua: START, WR1
Davante Adams: START, WR2
You don’t need me to tell you to start Puka Nacua. But did you know his name is actually Makea Nacua? “Puka” is a nickname given to him by his mother that means “chubby” in Samoan, given to him as a term of endearment because he was over 10 pounds at birth. Davante Adams suffered a hamstring injury in Week 3 and isn’t practicing at the time of writing. If he’s active, he’s starting for your fantasy team.
Tight End
Tyler Higbee: SIT
#BenchTheBee
Defense/Special Teams
Los Angeles Rams: STREAMER
Tied with Denver for the league lead in sacks with 12 and second in fumbles recovered with three, the Rams are streamable more often than not.